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april@madhedgefundtrader.com

Belly Busters

Biotech Letter

Did you know that more Americans are now trying to lose weight than trying to quit smoking? That's a staggering shift, and it has a lot to do with the buzz around those new obesity drugs.

Novo Nordisk (NVO) got the ball rolling in 2021 when they received the green light to market their diabetes drug, Ozempic, as a weight loss miracle called Wegovy. 

Not to be outdone, Eli Lilly (LLY) swooped in the fall of 2023 with Mounjaro – also a diabetes drug, sold as Zepbound – that got the FDA nod for weight loss, too.

Then, the whole pharma world, it seems, has started to go all-out on obesity, flooding the market with a whole new generation of weight loss drugs.

To date, there are 124 obesity meds in the works – a mix of 61 Phase 1 hopefuls, 47 in Phase 2, eight in Phase 3, and eight already greeting patients.

Remember that whole fen-phen disaster back in the 90s? That left a bad taste in everyone's mouth when it comes to weight loss drugs.

But things are different this time. These new obesity meds, especially those from Novo Nordisk and Lilly, are a game-changer. They're blowing those old weight loss pills out of the water.

It's not about fitting into those skinny jeans anymore (though that's a nice bonus). The focus is on health.

And while Novo Nordisk and Eli Lilly might be the big names in the obesity drug game, they've got competition. There's a whole crew of pharma companies jumping on the bandwagon, like Currax Pharmaceuticals, Roche (RHHBY), GlaxoSmithKline (GSK) – you get the picture.

But here's the really wild part about these drugs like Mounjaro and Wegovy, which use GLP-1 (Glucagon-like peptide-1) compounds to treat diabetes: They kinda stumbled onto their weight loss powers by accident.

Turns out, while they were busy helping diabetes patients, boom, patients started shedding pounds. Talk about a happy side effect.

As expected, this has created excitement in the market. Now, usually in the drug world, it's baby steps forward. A little better here, a bit less nausea there... yawn. 

But with eight of these drugs already in the late stages of development (Phase 3), expect even more surprises as potential breakthroughs could bypass traditional drug trial phases for a faster route to market.

Frankly, I'm shocked at the number of new mystery drugs suddenly popping up in early testing. Even those old-school Big Pharma players are jumping in: AstraZeneca (AZN), Novartis (NVS), Amgen (AMGN), and, heck, even Johnson & Johnson (JNJ) – everyone wants a slice of the obesity pie.

Now, this whole obesity meds craze reminds me of what happened with those PD-1 drugs in cancer treatment.

One good result, and suddenly everyone was scrambling to get their version to market.  But like in a reality TV show, not everyone makes it to the finale.

But what's the endgame in this obesity market expansion? Not 124 contenders, that's for sure.

Even right now, with everything in its early stages, you can already see which candidates have the potential. The competition's going to get fierce, and only the strongest drugs will survive.

Viking Therapeutics (VKTX), for example, has a dual GLP-1 and GIP agonist showing serious promise. After just 13 weeks, patients lost an average of 14.7% of their weight.

This data, released in February, proves Viking’s not just chasing the big pharma players; they're running right alongside them.

Now, over at Novo and Lilly, the pace hasn’t slowed down one bit either. Wegovy, which is Novo's contender in the ring, just got a nod in March for something a bit bigger than weight loss.

It’s been approved to tackle some serious heavyweights — cardiovascular deaths, heart attacks, and strokes in adults dealing with obesity or who are overweight. It's like getting a one-two punch for health.

As for Eli Lilly? They’ve been making some noise with tirzepatide, especially around metabolic dysfunction-associated steatohepatitis, or MASH for short.

They’ve got results showing that 74% of adults who were either overweight or obese managed to kick MASH to the curb without any increase in liver scarring after sticking with the treatment for 52 weeks.

Sadly, the biggest roadblock isn't the science, it's the money. It’s not just about making these drugs. It’s about getting them into the hands of those who need them most.

The current scene? A bit of a heartbreaker.

Most US insurance companies are drawing the line at covering Wegovy or Zepbound for obesity. This leaves a hefty bill on the table, putting these potentially life-altering treatments out of reach for many.

Think about it – the people who could benefit the most, maybe those on Medicaid or living paycheck to paycheck, are staring at a closed door. And let’s not even get started on Medicare, which, as of now, can’t even touch these drugs.

It’s a strange paradox, isn’t it? The very treatments that could lift the weight of obesity off society’s shoulders are dangling just out of reach for many.

So, now, the burning question isn’t so much about whether these treatments can make shareholders and companies do a happy dance. It’s more about where we’re heading.

Think about cancer treatment – the sickest patients get the cutting-edge drugs first.  What would that even look like in obesity? 

Will all these 124 experimental options help level the playing field, finally forcing insurers to step up? Only time will tell.

As of now, the obesity treatment field is going through a revolution. While the market faces challenges like accessibility, I suggest you closely monitor the progress of key players like Novo Nordisk and Eli Lilly.

Consider smaller, innovative companies, such as Viking Therapeutics, for potential high-risk, high-reward investments as well.

 

 

 

 

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april@madhedgefundtrader.com

April 9, 2024

Biotech Letter

Mad Hedge Biotech and Healthcare Letter
April 9, 2024
Fiat Lux

 

Featured Trade:

(A PHARMA TORTOISE IN A MARKET FULL OF HARES)

(JNJ)

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A Pharma Tortoise In A Market Full Of Hares

Biotech Letter

For the thrill-seekers who get a kick out of watching industries move faster than a cat on a hot tin roof, riding the wave of trending growth stocks might be for you.

But for those who prefer a good night's sleep over night sweats about market swings, pinning down stocks that promise a smooth sail towards retirement is the name of the game.

Now, if I were to put my money on one sector that's as steady as they come, I'd bet the farm on healthcare.

Why, you ask? Well, let’s take a look at the numbers.

U.S. healthcare spending ballooned to a jaw-dropping $4.5 trillion in 2022. That’s $13,493 for every man, woman, and child. With an army of about 10,000 baby boomers daily marching into Medicare eligibility, it's a safe bet this number's on a one-way trip up.

Let’s talk about a healthcare giant arena that might not make you rich overnight, but it's a dividend machine you can count on: Johnson & Johnson (JNJ).

Think of J&J as the responsible older sibling of your portfolio. They recently raised their dividend for the 61st year in a row. That's a 3.1% yield right now – a pretty good return for such a dependable company.

Over the past five years, J&J’s payout has beefed up by over 25%. Quite the feat, especially considering it just slimmed down by spinning off its consumer health division.

This strategic move has made J&J a lean, mean, dividend-paying machine. They're now laser-focused on their core businesses: med tech and pharmaceuticals.

This focus is paying off – they raked in a sweet 11.1% jump in adjusted earnings in 2023. With dividends sitting pretty at $4.76 a share and a clear path for growth, this blue chip just keeps getting better.

But J&J's not just a big fish in the healthcare pond – it's practically the whole ocean. They hauled in a jaw-dropping $85.2 billion in revenue last year. This company has a decades-long track record of turning its massive size into consistent growth for shareholders.

Case in point: J&J just made a big power play, grabbing Shockwave Medical (SWAV) for a cool $13.1 billion. 

Not bad for a company that clearly loves shopping for heart-focused companies – remember when they scooped up heart device maker Abiomed for $16.6 billion in 2022? This latest acquisition isn't just about beefing up their medical device game. It's their ticket to dominating the cardiovascular space.

But, J&J's not content with just hearts; they're setting their sights on robot-assisted surgery with their new Ottava device. 

Sure, they might be playing catch-up to Intuitive Surgical (ISRG), but think about it: barely any surgeries use robots right now. This market has potential written all over it

Of course, it's not all sunshine and roses in the land of Big Pharma. J&J's had its share of courtroom battles and regulatory headaches, just like any mega-corporation.

But they've weathered the storm, and their credit rating is better than Uncle Sam's. That shows a kind of resilience you just can't fake.

In today's volatile market, it's easy to get swept up in the hype of flashy, high-risk stocks – the hares of the investing world. But what if true wealth lies in the slow and steady pace of the tortoise?

In the pharma world, J&J is proof that slow and steady progress, unwavering reliability, and a continuous effort to innovate are the secrets to long-term success. They might not be the flashiest stock, but their steady march of growth and consistent dividends make them a quiet force in the pharma world. 

So the next time you're tempted to chase the latest market fad, remember the pharma tortoise – and consider adding a reliable blue-chip like J&J to your portfolio. If you see a dip, don't hesitate, buy it.

 

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2024-04-09 12:00:212024-04-09 11:02:45A Pharma Tortoise In A Market Full Of Hares
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April 4, 2024

Biotech Letter

Mad Hedge Biotech and Healthcare Letter
April 4, 2024
Fiat Lux

 

Featured Trade:

(A HIGH RISK, HIGH REWARD BIOTECH)

(VYGR), (SNY), (ABBV), (NBIX), (NVS), (AZN), (SGMO), (BIIB), (RHHBY), (IONS)

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A High Risk, High Reward Biotech

Biotech Letter

Voyager Therapeutics (VYGR) has put investors through the wringer. Since going public in 2015, their chips have swung wildly, from a high-rolling $30 down to a "you've got to be kidding me" $2.50. Why? Well, their early bet on curing neurological diseases hit some snags.

But, things seem to be turning around for them these days. Word on the street is Voyager's new Alzheimer's drug could be a total game-changer. If those clinical trials get the FDA's blessing, their stock could skyrocket from its current $9.30 to $22 a share.

Before anything else, let's take a stroll down memory lane.

Voyager started out with big dreams – using fancy gene therapies to tackle tough brain diseases like Parkinson's and Huntington's.  Sadly, those early programs didn't quite deliver.

But hey, they caught the eye of some big pharma players. Sanofi (SNY) came knocking with a sweet deal – $100 million upfront and promises of up to $745 million if things worked out. Unfortunately, the science wasn't cooperating, and Sanofi bailed in 2019. Ouch.

Not to be discouraged, Voyager hooked another giant, AbbVie (ABBV), with a $1.2 billion deal for Alzheimer's and Parkinson's drugs. But then, more bad luck – their Parkinson's drug stumbled, and their Huntington's disease trials got put on hold. So, AbbVie decided to cut their losses in 2020.  Double ouch.

And while the pandemic may have cured our boredom, it killed investor patience with unproven biotechs. Voyager's stock price cratered, leaving them worth about as much as a used napkin – barely more than their own $500 million cash pile.

But Voyager, bless their stubborn hearts, refused to become a biotech graveyard. 

Despite having zero products actually making money, they have a secret weapon: their TRACER capsid tech. Think of it as a tiny Trojan Horse that can sneak drugs past that blood-brain barrier and deliver them directly to their target. Pretty impressive, right?

This tech, along with Voyager's brainpower, caught the eye of some pharma giants. 

We're talking big names like Neurocrine Biosciences (NBIX), Novartis (NVS), AstraZeneca (AZN), and Sangamo (SGMO). If everything goes according to plan, these partnerships could be worth a whopping $8 billion. Now that's what I call a vote of confidence — or maybe just a collective case of gambling fever.

For Voyager, however, its biggest gamble is on Alzheimer's – and they're going all-in.  Their star player is an antibody that tackles those nasty tau tangles that mess up brain cells.

Here’s a bit of context to understand why treatments for this are crucial.

Tau is like the scaffolding inside your neurons, keeping everything organized. But in Alzheimer's, that tau goes rogue, clumping into nasty tangles. Think of it like a giant hairball clogging up the brain's communication system. These tangles are called neurofibrillary tangles (NFTs) if you want to sound super smart.

This is something that Big Pharma like Biogen (BIIB), AbbVie, and Roche (RHHBY) are trying to target, too. But Voyager claims theirs is a precision weapon, zeroing in on just the bad stuff. If clinical trials prove that, their drug could blow the competition out of the water.

Plus, Voyager's got another trick up their sleeve: a gene therapy that hits the “off” switch on those tau tangles. They've shown it works in animals, and Biogen and Ionis (IONS) are already testing something similar in humans. But Voyager's got the edge – theirs is a one-time shot, so no more of those painful spinal taps.

That’s not all. Voyager is also tinkering with these new virus capsules that can sneak gene therapies straight into brain cells. And get this – they're even working on ways to ditch the viruses altogether and target nerves directly. Pretty cutting-edge stuff.

So, is Voyager a surefire win? Heck no.

Let's be realistic. It's going to be a while before Voyager actually makes money from these drugs. But there'll be exciting news along the way—science proving their ideas work.

Remember, the tricky thing with gene therapies is that everyone's chasing the same dream: how to get these treatments where they need to go quickly, cheaply, and safely.  It's tough to predict who'll crack the code, even for the experts.

What's noteworthy about Voyager is that they keep reeling in those big pharma partners. Sure, the first two deals fizzled out, but not before Voyager pocketed a ton of cash.  That kept them afloat, and now their stock's not such a dumpster fire.

But, let’s face it. Voyager's track record isn't exactly a parade of victories. Progress has been slow, and that's just the way it is in this industry.

If they pull off a miracle cure, they'll be worth billions, maybe tens of billions. Remember when Intellia Therapeutics (INTL) hit that $10 billion mark? That's the kind of payoff we're talkin' about.

Still, Voyager needs to deliver some serious wins, or those partners will vanish again. However, it’s worth considering that when a big player like Novartis, who knows this gene therapy game, partners up... that's gotta mean something, right? Even without results from human trials, it's a sign Voyager might be onto something big.

I know it's hard to justify investing in small biotechs with a losing streak, especially when they're tackling the toughest diseases out there. But after digging into Voyager, I can see its potential.

Worst case scenario? Their drugs flop. But that can happen to any biotech, even those with huge valuations and decades of trying.

As for Voyager, this biotech has been around the block. They've clearly got some promising science, and their stock is cheap.  For me, that's enough to take a small position and see what happens.

 

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2024-04-04 12:00:092024-04-04 12:28:17A High Risk, High Reward Biotech
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April 2, 2024

Biotech Letter

Mad Hedge Biotech and Healthcare Letter
April 2, 2024
Fiat Lux

 

Featured Trade:

(BREATHE EASY)

(MRK), (JNJ)

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Breathe Easy

Biotech Letter

It looks like Merck (MRK) just scored a major touchdown in the drug wars, which might make the looming Keytruda patent expiration sting a little less.

Remember when Merck dropped $11.5 billion on Acceleron back in 2021 to get their hands on Winrevair (then known as Sotatercept)? That was a seriously gutsy move to soften the blow when their Keytruda goldmine started drying up.

Talk about a gamble. Acceleron didn't even have their Phase 3 trial results in hand yet. A lot of people were scratching their heads at the time, thinking maybe Merck had lost their marbles. 

But fast-forward to today, those Phase 3 results drop, and here we are. Turns out Merck knows a thing or two about playing the long game.

Their new drug, Winrevair, which just got the FDA thumbs up for a rare heart condition, tackles a serious heart condition called pulmonary arterial hypertension (PAH).

PAH is no joke – it basically strangles your lungs and heart, drastically shortening your lifespan. Unlike those old PAH drugs like Uptravi from Johnson & Johnson (JNJ), Winrevair's got a completely different way of fighting back. That could be huge for patients who aren't getting enough relief with current options.

Winrevair targets that messed-up TGF-beta pathway, trying to reverse some of the damage caused by this disease.

Although PAH might be rare, affecting an estimated 15 to 50 people per million in the United States and Europe, those who suffer from it are often desperate for effective treatments.

The global PAH market is already worth a staggering $7.3 billion annually and is projected to hit $12.18 billion by 2032.

Merck's timing couldn't be better. Not only did Winrevair sail through approval, but it also dodged all those nasty black box warnings and extra safety hoops some drugs have to jump through.

Translation: this drug is about to hit the market full speed ahead.

Given the promise of this new drug, Merck must be popping champagne corks right about now. No restrictions mean doctors can prescribe this stuff far and wide – that's a probable goldmine, especially for a serious disease like PAH.

Let's not forget why all this matters. Keytruda was a $25 billion cash cow for Merck in 2023, making up a huge chunk of their revenue.  Those cheap knock-offs are coming in 2028, ready to eat into that sweet slice of the pie. 

But thanks to Wenrevair, that future doesn’t seem too daunting anymore.

Merck has set a price of $14,000 per vial for Winrevair, translating to an average annual cost of $212,000 per patient. While this may seem steep, it reflects the drug's potential to improve the lives of PAH sufferers and secure Merck's financial future.

Actually, analysts are predicting peak sales of a mind-boggling $11 billion – maybe even $8 billion at the low end.  Either way, that's a massive lifeline for Merck as they brace for the dreaded Keytruda patent cliff in 2028.

In fact, Winrevair could pull in $500 million this year alone, jumping to $3 billion by 2027. Talk about a growth spurt.

With Winrevair set to change the PAH treatment landscape, investors can breathe easy knowing that Merck has a new ace up its sleeve.

After all, this drug is practically guaranteed to be another blockbuster, which is great news considering the looming Keytruda patent expiration in 2028.

Merck's audacious $11 billion bet on Acceleron seems to be paying off – Winrevair could easily bring in $30 billion over its lifespan.

But let's not get too carried away – Winrevair won't single-handedly save Merck in the long run.  They'll need more hits to keep outperforming the competition.

For now, Merck seems like a decent hold. It's got reasonable growth potential, and you might even want to nab some shares if the price dips.

 

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april@madhedgefundtrader.com

March 28, 2024

Biotech Letter

Mad Hedge Biotech and Healthcare Letter
March 28, 2024
Fiat Lux

 

Featured Trade:

(WALL STREET'S NEW HAPPY PILL)

(JNJ), (SEEL), (NUMI), (AITAI)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2024-03-28 12:02:482024-03-28 12:06:41March 28, 2024
april@madhedgefundtrader.com

Wall Streets New Happy Pill

Biotech Letter

Who would've thought a drug that was once the go-to for keeping soldiers from feeling their limbs getting stitched up in 'Nam would find itself in the limelight, decades later, for something entirely different?

And who's the reason behind this resurgence? None other than Mr. Elon Musk, alongside memories of Matthew Perry, and a growing chorus of folks battling the blues.

Musk, in one of his late-night (or is it early morning?) tweet-a-thons and in a recent interview with Don Lemon, drops that he's dabbling in ketamine — not for kicks, but for a "negative chemical state," doctor's orders, of course. Once every couple of weeks, a small dose.

This coming from a guy who's brainstorming how to send us to Mars while running a social media circus.

Now, before we dive deeper, here's a quick primer on ketamine.

Born in the labs of Parke Davis in the 60s and tested on unsuspecting prisoners (yikes), it was the anesthetic dream.

By 1970, ketamine earns the FDA's gold star as a trusty anesthetic. But here's where it gets interesting – patients start raving about feeling surprisingly chipper after surgery.  Scientists, naturally, get that “wait a minute, that's not supposed to happen” look on their faces.

By the time the 90s rolled in, scientists had discovered that this battleground drug might be a secret weapon against depression.

All those positive patient reports sparked a firestorm of studies, and suddenly ketamine's the underdog superhero taking on treatment-resistant depression, PTSD, and more.

Fast forward to 2019, and the FDA green-lights a derivative, esketamine, delivered via nasal spray, marking a new era in the treatment of severe depression.

Interestingly, despite esketamine’s presence in the market, doctors are still heavily prescribing the original stuff. Why?

Because it works, undeniably so, and those prescriptions are through the roof – up fivefold since 2017.

Actually, despite being a bit player compared to the heavyweight category of cancer research, mental health is a quietly exploding segment.

In fact, the market for ketamine's mental health revolution is massive, and that's not just feel-good talk. We're looking at over 264 million people globally battling depression alone. 

Add to that the millions more struggling with PTSD, OCD, and a growing list of treatment-resistant conditions – it's a staggering potential patient base. 

With mental health taking center stage these days, analysts predict the ketamine market could explode to $1.05 billion by 2027. That translates to a CAGR of 16.5% from 2020 – not just growth, but a serious acceleration.

Naturally, this has companies salivating. Big pharma like Johnson & Johnson (JNJ) is in the game – their Spravato spray raked in $164 million in 2020, and that was just their opening act.

But the real excitement is with the innovators: companies like Seelos Therapeutics (SEEL), with their focus on new delivery methods, Numinus Wellness (NUMI) building out a whole network of ketamine-assisted therapy clinics, and ATAI Life Sciences (ATAI) betting big on psychedelic-focused research.

So, are you seeing those dollar signs flashing yet? Because with ketamine, there might just be some serious gold to be found. 

Sure, J&J's pulling in the cash, but that's just the tip of the iceberg. The companies blazing the trails – tweaking formulas, reimagining delivery methods, building whole new treatment models – those are the ones with that “make it big” potential.

Still, it’s important to be realistic here. After all, biotech investing is a rollercoaster, not a Sunday stroll. We're talking FDA approvals, trial setbacks, the whole wild ride.

Ketamine, with its trippy backstory and game-changing possibilities, is the embodiment of that risk-reward gamble. Its story is about second chances, unexpected breakthroughs, and pushing the limits of what we thought possible for mental health. And yeah, it's also about those sweet, sweet returns for investors willing to take that leap.

So here's my suggestion: throw this drug, and the companies pushing the envelope with it, straight onto your watchlist. Keep tabs on the clinical trials, the news about those new delivery methods, the regulatory updates.

This space is just getting warmed up, and you don't want to miss the boat when things start taking off. Ketamine might have started out in the shadows, but its future? Well, that could shine pretty bright.

 

 

 

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april@madhedgefundtrader.com

March 26, 2024

Biotech Letter

Mad Hedge Biotech and Healthcare Letter
March 21, 2024
Fiat Lux

Featured Trade:

(THE TOP DOG IN ANIMAL HEALTHCARE)

(ZTS), (AMGN), (PFE), (JNJ), (ELAN)

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