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Biotech’s Gray Fox

Biotech Letter

Every investor has a stock they own, not for the adrenaline rush but for the steady hand it provides. Years ago, that meant a ladder of Treasuries and a bottle of Tums. Today, it might just be Amgen (AMGN).

You won’t find it trending on Reddit or being whispered about in hedge fund chatrooms. It’s not running on AI hype or meme magic.

Instead, what you will find is a dependable biotech veteran with a strong dividend, a rock-solid balance sheet, and a quietly impressive pipeline that’s starting to show some real muscle.

After a modest pullback, Amgen looks more attractive than it has in some time.

At first glance, it looks like a mature drugmaker doing what mature drugmakers do: collect royalty checks, keep the dividend stable, and try not to screw up.

But the story under the surface is getting more interesting. There’s real optionality here, and the market isn’t fully pricing it in.

And after a 12% dip from the highs, you’re getting paid to look closer.

Let’s start with Horizon Therapeutics. The acquisition caught some flak. Analysts grumbled about the price tag. Regulators kicked the tires.

But here we are, and Horizon’s drugs, Tepezza and Krystexxa, are settling in just fine.

Amgen didn’t buy hype. It bought cash flows. And given the early returns, it may have paid less than it looks.

Then there’s biosimilars. For years, they were treated like biotech’s version of knockoff handbags: low prestige, thin margins, more trouble than they’re worth. But Amgen saw the long game.

With Amjevita now in the US market gunning for Humira, it’s not about prestige, it’s about volume and execution. This has now stopped being a side hustle but a new and sustainable business line.

The pipeline, meanwhile, is quietly moving.

Tarlatamab for small cell lung cancer isn’t just a science experiment. It’s a T-cell engager with real data and serious upside. Olpasiran in cardiovascular disease? A potential blockbuster in the making.

These aren’t blue-sky R&D. These are real stuff with clear paths to approval. And it doesn’t hurt that Amgen knows how to get drugs through the FDA without a parade of surprises.

Now, put Amgen next to the usual suspects.

AbbVie (ABBV) still leans heavily on Skyrizi and Rinvoq to patch the Humira hole, and the market’s still waiting for proof.

Pfizer (PFE) is wandering through the COVID hangover, unsure of what it wants to be when it grows up.

Amgen, by contrast, is paying a 3.4% yield, raising that payout annually, and generating $11 billion in free cash flow. It’s not a turnaround story. It’s a continuation of competence.

And here’s the kicker. Despite all this, the stock has pulled back. Not because of a missed quarter or bad data, but because biotech fell out of favor.

No headlines. No blowups. Just a valuation gap waiting for someone to notice.

That kind of disconnect reminds me of a trade I made years ago in Regeneron (REGN). The market had written it off. Too mature, too slow, too quiet.

But under the surface, the pipeline was humming. Optionality was there – you just had to know where to look. That position ended up outperforming expectations by miles, not because I caught lightning in a bottle, but because the market mispriced quiet competence.

Amgen sits in that same zone today. It’s not a party stock. It doesn’t need to be. It’s the kind of name you own because you like getting paid while management does its job.

It’s not a moonshot, but it’s not priced like one either. And if even half of the pipeline delivers, this stock could quietly rerate before most people notice what changed.

If you believe that real value still matters in a market crowded with noise, Amgen is worth your time. It’s yielding, compounding, and positioning itself for another chapter of relevance. No gimmicks, no theatrics, just serious business in a space that rewards it.

And if that sounds too boring for some, well, they can keep chasing the next shiny thing. I’ll take a company that pays me to wait…especially when there’s something worth waiting for.

 

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