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Tag Archive for: (GILD)

Mad Hedge Fund Trader

April 24, 2020

Diary, Newsletter, Summary

Global Market Comments
April 24, 2020
Fiat Lux

Featured Trade:

(APRIL 22 BIWEEKLY STRATEGY WEBINAR Q&A),
(SPY), (INDU), (GILD), (NEM), (GOLD), (USO),
 (SOYB), (CORN), (SHOP), (PALL), (AMZN)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-04-24 09:04:452020-04-24 09:10:08April 24, 2020
Mad Hedge Fund Trader

April 23, 2020

Biotech Letter

Mad Hedge Biotech & Healthcare Letter
April 23, 2020
Fiat Lux

Featured Trade:

(POST-PANDEMIC STOCKS TO DIVERSIFY YOUR PORTFOLIO)
(BPMC), (NVTA)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-04-23 10:02:142020-04-23 16:17:33April 23, 2020
Mad Hedge Fund Trader

April 21, 2020

Biotech Letter

Mad Hedge Biotech & Healthcare Letter
April 21, 2020
Fiat Lux

Featured Trade:

(GETTING YOU BANG PER BUCK WITH ALEXION PHARMACEUTICALS)
(ALXN), (GILD), (RHHBY), (REGN), (SNY)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-04-21 04:02:062020-04-20 21:01:41April 21, 2020
Mad Hedge Fund Trader

Getting You Bang per Buck with Alexion Pharmaceuticals

Biotech Letter

Since nobody can actually control when to get sick or what type of disease to acquire, it makes absolute sense that biotech stocks remain one of the wisest bets if you want to put your hard-earned cash to work.

The question, therefore, is what are the best biotech stocks to buy now?

Looking at the biotechnology stock prices today, I can say that Alexion Pharmaceuticals (ALXN) will give you the most bang for your buck.

For over a decade, this ultra-rare-disease biotechnology company had been regularly valued at roughly 22 to 67 times its cash flow and frequently well above 30 times forward EPS.

Now, you can buy this top biotech stock for less than eight times its Wall Street profit consensus in 2021 and 10 times its cash flow for next year as well. It definitely doesn’t hurt that its PEG ratio is less than 1, categorizing it as an “undervalued” stock today.

However, its attractive pricing isn’t the only thing that’s putting Alexion in the news these days as this biotech company has been active in the race to find a coronavirus cure since early February.

When news about the pandemic broke, Alexion decided to repurpose its rare chronic blood disease bestseller Soliris as a potential COVID-19 treatment since the drug showed promising results on patients with severe pneumonia or acute respiratory distress syndrome.

Alexion’s efforts have been quite promising so far, with the biotech company targeting to commence a Phase 2 study of Soliris within the month. What we know so far is that this experiment will involve 10 patients as part of the proof-of-concept trial.

Apart from Alexion, other top biotech companies repurposing old drugs in search of a COVID-19 cure are Gilead Sciences (GILD) with Remdesivir, Roche (RHHBY) with Actemra, and Regeneron (REGN) and Sanofi (SNY) with Kevzara.

Outside its coronavirus treatment efforts, Alexion actually prides itself on a promising pipeline. To date, three treatments are projected to turn into blockbusters soon.

The first is Strensiq, which is formulated to treat a rare disease commonly known as hypophosphatasia. Patients with this disorder have an enzyme deficiency, making them unable to properly process calcium and phosphorus. As a result, they end up with malformed bones and teeth.

The second treatment is Kanuma, which is for patients suffering from lysosomal acid lipase (LAP) deficiency. People with this condition lack a key enzyme, preventing them from effectively breaking down fats.

Both conditions are extremely rare. Hypophosphatasia affects only 1 in 100,000 people while LAP is suffered by 1 in 40,000 individuals.

The third treatment is Ultomiris, which is widely regarded as Soliris’ successor.

For years, Soliris has been Alexion’s major moneymaker. However, uncertainties on the company’s hold on its patent exclusivity have started to shake investors’ faith in this stock. With one of Soliris’ key patents set to expire in 2021, the biotech company has to brace itself for the onslaught of generic competition.

This is where Ultomiris comes in.

Alexion has been busy migrating its customers to opt for Ultomiris before Soliris’ key patent expires.

To make this offer enticing, the biotech company has priced the newer drug to be slightly cheaper than the old blockbuster. Ultomiris costs $458,000 while Soliris is priced at $500,000.

To sweeten the deal further, the newer treatment is only required once every eight weeks. In comparison, Soliris’ treatment schedule is bi-monthly.

Basically, it’s as if Alexion has effectively restarted the clock in its patent exclusivity on this ultra-rare disease indication. The company aims to convert at least 70% of its users by mid-2020.

From a financial point of view, Alexion is performing quite well. Its fourth-quarter report showed that the company earned $1.4 billion in revenues, demonstrating a 23% increase from the same quarter in 2018.

Meanwhile, it raked in $5 billion in full-year sales for 2019. This indicated a 21% jump from its relatively paltry sales of $4.1 billion.

Looking at the metrics, Alexion is one of the surprisingly cheap stocks considering its growth. It also has the added bonus of dominating its chosen ultra-rare disease space.

This is typically a good strategy to avoid competition while also being able to seek high price points for its innovative treatments. The fact that insurers generally cover these treatments all but guarantees that Alexion is secure in terms of cash flow predictability.

Despite the panic induced by the coronavirus market, investing opportunities are everywhere --- if you know where to look.

Alexion is a solid company with strong growth prospects and is selling at a reasonable price. Any opportunistic investor worth his salt would know that this is the ideal time to strike.

 

https://www.madhedgefundtrader.com/wp-content/uploads/2020/04/alxn.png 111 255 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-04-21 04:00:032020-04-20 21:01:23Getting You Bang per Buck with Alexion Pharmaceuticals
Mad Hedge Fund Trader

The Race to Find a Corona Cure

Biotech Letter

Naturally, many people are wondering about which stocks to own in light of the coronavirus. The latest development on the race to find a coronavirus cure is a joint effort involving two giant names from the biotechnology industry: Regeneron Pharmaceuticals (REGN) and Sanofi (SNY).

Taking a page off Gilead Sciences’ (GILD) move to recycle HIV drug Remdisivir and Roche Holding’s (ROG) decision to utilize rheumatoid arthritis Actemra, Sanofi and Regeneron are looking into an existing drug’s ability to offer refuge for patients suffering from COVID-19.

According to a recent announcement, the two companies are looking to test rheumatoid arthritis medication Kevzara on COVID-19 patients.

This drug was initially approved in 2017 and while it failed to reach blockbuster status at the time, Sanofi and Regeneron are preparing to transform it into the next leader in this pandemic race.

It should be noted though that Kevzara is not a coronavirus cure. Rather, the companies are hoping to use this drug to combat the symptoms related to COVID-19.

This is why it’s promising.

When a person gets infected by the novel coronavirus, the immune system is activated and starts attacking the virus to protect the body. As time passes, the immune system goes into overdrive and ends up overreacting, causing additional damage.

Gradually, the immune system starts attacking even the healthy tissue and organs as with the case for some COVID-19 patients.

This means that the coronavirus is causing an accelerated response from the immune system resulting in the patients’ damaged organs starting with the lungs.

This is where Kevzara comes in.

The drug functions as an inhibitor of the protein that triggers the patient’s immune and inflammatory response.

That is, Kevzara can stop the body from attacking itself despite the triggers caused by the coronavirus.

In terms of the specifics of this joint effort, Regeneron will take the lead for the US trials while Sanofi will be in charge of international efforts.

Aside from Kevzara, both Regeneron and Sanofi have been pursuing separate leads on how to deal with the pandemic.

Sanofi has been working in tandem with the US Department of Health and Human Services (HHS), specifically with the Biomedical Advanced Research and Development Authority (BARDA), to come up with a coronavirus vaccine. 

However, it’s the coronavirus efforts of Regeneron that gained much attention in the past weeks.

In February, Regeneron and the HHS expanded their partnership to come up with potential COVID-19 treatments. So far, the biotechnology giant has decided to work on monoclonal antibodies via its VelocImmune platform.

This avenue is particularly promising since Regeneron has already come up with an antiviral drug to combat Ebola. Its collaboration with HHS has also already resulted in plans to develop a MERS treatment, which is also a type of coronavirus.

According to Regeneron executives, the company will have a coronavirus treatment ready for human testing by August. If all goes well, then it aims to produce 200K prophylactic doses.

Although its innovative coronavirus proposals are exciting, Regeneron remains focused on its older and more dependable money makers particularly the eye drug Eylea.

This strength is in display in Regeneron’s fourth quarter results, which showed better than expected numbers.

For Eylea alone, the company generated an 11% year-over-year growth in sales.

Despite the emergence of new competitors like Novartis’ (NOVN) Beovu, Regeneron’s eye drug remains the leading product in this sector. In fact, Eylea managed to cross $2 billion in global sales just for the year 2019.

As for inflammation-reducer Dupixent, the treatment’s global sales climbed 136% in 2019.

Meanwhile, revenue from its cancer immunotherapy Libtayo soared to over quintuple from the previous period.

Building from the strength of Eylea, Regeneron also announced its successful late-stage clinical study that aimed to expand the indication of the drug to moderately severe to severe non-proliferative diabetic retinopathy (NPDR).

If this Eylea expansion pushes through, then Regeneron has yet another blockbuster drug in its hands.

In the past five years, Regeneron has demonstrated a strong EPS growth, growing by 23.74% annually. Given its recent performance and based on forward-looking statements, the company can be expected to report an average of 17.4% growth on its EPS in the next two years. 

Amid the panic and confusion caused by the coronavirus pandemic, it’s crucial to remain objective, especially with the stock market.

Before making a decision, ask yourself this question: “Will this current situation change the 10-year or even the 20-year outlook for the financial sector?” 

Despite the paranoia proliferating in the market in the past months, I believe the answer to this question is still a resounding “no.”

For now, it would be wise to treat owning stocks like how to own businesses. It's important to think about which stocks to own during the coronavirus, but don’t do it just to make a quick buck. Rather, take a look at lasting and stable companies with the capacity to not only grow over the years but also to compound their returns.

stocks to own during the coronavirus

 

stocks to own during the coronavirus

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-03-19 09:00:262020-04-26 23:01:30The Race to Find a Corona Cure
Mad Hedge Fund Trader

March 12, 2020

Biotech Letter

Mad Hedge Biotech & Healthcare Letter
March 12, 2020
Fiat Lux

Featured Trade:

(GILEAD SCIENCES’ CORONA BOOM)
(GILD), (FTSV), (SNY)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-03-12 09:02:442020-03-12 09:44:46March 12, 2020
Mad Hedge Fund Trader

Gilead Sciences' Corona Boom

Biotech Letter

The possibility of a pandemic is a terrifying thought. Nowadays though, you can’t switch on the news or surf the Internet without seeing reports about the worldwide spread of the coronavirus disease (COVID-19). Unfortunately, the fear that we once hoped to never be realized has become a reality.

The World Health Organization (WHO) has officially declared the coronavirus disease a pandemic.

The numbers are rising at an alarming speed, with over 1,300 confirmed cases in the United States alone and approximately 129,000 worldwide. As for the mortality rate, more than 4,700 people have died from this coronavirus disease.

Unsurprisingly, financial markets have taken a hit in recent weeks in response to the outbreak. The potential of an uncontrollable pandemic has wreaked havoc in the global economy instilling fear among investors.

With economists predicting that a full-scale pandemic could throw not only the US but also many developed countries into recession, the public has brace themselves for what lies ahead.

While a lot of companies are raking in profits enough to keep the wolf from the door, one biotechnology stock has been on a roll since the coronavirus outbreak went public: Gilead Sciences (GILD).

To date, Gilead has been hailed as possibly our best hope in discovering an effective treatment for the coronavirus.

Aside from being the first biotechnology stock to offer a solution to the outbreak, Gilead has another advantage over its rivals. It no longer has to start from scratch. Instead, the company reused Remdesivir, which is a drug it previously developed to cure Ebola but failed.

Basically, Remdesivir is designed as an antiviral drug that helps patients fight off viral infections. That means it targets not only the Ebola virus but also other types of viruses including SARS and MERS.

Since SARS and MERS are caused by the coronavirus as well, health experts believe that Remdesivir could be a treatment for COVID-19.

On January 31, doctors administered a dose of Remdesivir on a COVID-19 patient and discovered that the drug reversed almost all the major symptoms.

If Remdesivir proves to be the key to solving the COVID-19 outbreak, then Gilead will not only experience a massive performance boost but might even end up saving the world from a recession.

Despite this promising development, Gilead isn’t putting all its eggs in just one basket. 

The company has recently made its first major purchase in three years in the form of a $4.9 billion acquisition of cancer biotechnology company Forty Seven (FTSV) — approximately twice as much as the latter’s market cap.

Gilead’s main draw for this huge deal is FTSV’s promising lead pipeline candidate Magrolimab, which is a treatment that targets various types of cancer such as myelodysplastic syndrome and acute myeloid leukemia.

What sets apart Magrolimab is that it targets CD47, which is typically called the “don’t eat me signal” molecule that cancer cells utilize to circumvent the immune system.

Although Magrolimab is still in its trial phase, the treatment showed a notable 40% response rate for hard-to-treat blood cancers and 50% for Myelodysplastic syndrome. The drug is also getting tested for lymphoma and ovarian, bladder, and colorectal cancers.

This latest deal is in line with some of Gilead’s biggest acquisitions in recent years like its $11.9 billion deal with cancer immunotherapy developer Kite Pharma in 2017.

Apart from these, Gilead has expanded its $5 billion partnership with Galapagos (GLPG) in the hopes of finally bringing another blockbuster in its lineup.

The two have been working on  rheumatoid arthritis (RA) and Crohn's disease treatment Filgotinib, which has the potential to bring at least $1.3 billion in revenue in the next five years.

Once it hits the market, Magrolimab is expected to rake in $800 million to $1 billion in peak sales.

Although Gilead’s deal with Forty Seven has the highest price tag, it wasn’t the only acquisition of smaller immuno-oncology companies that happened recently. Merck (MRK) acquired AqQule for $2.7 billion while Sanofi (SNY) purchased Synthorx for $2.5 billion.

The COVID-19 pandemic has provided an unexpected opportunity for Gilead, and there’s no doubt that Remdesivir’s success will contribute to the company’s profits this year.

However, Gilead’s most promising growth driver is the rheumatoid arthritis lineup it’s developing with Galapagos. On top of these, it’s immuno-oncology pipeline is also shaping up to have some of the most exciting and promising candidates particularly for rare diseases.

The coronavirus pandemic has infused panic among the public, with more and more stocks getting dumped based on alarm and confusion. But as terrifying as this situation is, the best way to handle it is to remain calm and to put things in perspective.

Remember, solid companies will continuously achieve success in the long run no matter the temporary drawbacks in their stock prices. Buy those shares and simply hold on to them. Your future self will be grateful for that decision.

As fear continues to take over a lot of investors’ strategies, let me share with you one of my favorite pieces of advice from Warren Buffett: “Be fearful when others are greedy and be greedy when others are fearful.”

https://www.madhedgefundtrader.com/wp-content/uploads/2020/03/gilead.png 375 750 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-03-12 09:00:572020-03-12 09:44:30Gilead Sciences' Corona Boom
Mad Hedge Fund Trader

March 10, 2020

Biotech Letter

Mad Hedge Biotech & Healthcare Letter
March 10, 2020
Fiat Lux

Featured Trade:

(A NEW TECHNOLOGY TO EDIT GENES HITS THE MARKET)
(MRNA), (GILD)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-03-10 15:02:262020-03-10 15:37:24March 10, 2020
Mad Hedge Fund Trader

A New Technology to Edit Genes Hits the Market

Biotech Letter

The biotechnology market is estimated to surge over $775 billion by 2024 as experts in this sector continue to discover cutting-edge treatments for thousands of previously incurable diseases.

While gene-editing therapies have been dominating the rare disease field in the past years, Moderna Inc (MRNA) has been working on a novel but supposedly more effective solution.

Instead of altering the genes via the DNA of a person to treat the sickness, the company strengthens the messenger RNA (mRNA) to help the body fight the disease on its own.

Here’s Moderna’s take on why its treatments are more sustainable and effective in the long run.

Unlike DNA-based therapies, which target the nucleus of the cell, Moderna is developing mRNA treatments. According to the company, their method would be easier to implement compared to the more commonly used technique.

This is because the DNA is stored solely in the cell’s nucleus, which makes it difficult to access. In comparison, mRNA can be found throughout the cell, making it more readily available.

Moderna uses the same logic in developing its vaccine for the coronavirus disease (COVID-19) --- and they might have just hit the nail in the head here.

Since the coronavirus outbreak, Moderna has been at the forefront of the crisis. Using its patented technology, the company recently announced that it has created a new vaccine against this potential pandemic.

In fact, the first batch of COVID-19 vaccine called mRNA-1273 was already shipped to the National Institutes of Health for testing.

The first trial for this vaccine, which will include 20 to 25 volunteers, will be completed by April. Initial clinical data is estimated to be released by July or August.

Given the complexity of the situation and the limited information we have about the coronavirus, Moderna’s response was actually quite impressive.

After learning about the genetic composition of the coronavirus, the company was able to develop a potential vaccine in less than two months.

To put things in a better perspective, keep in mind that there are only two companies that have something to show for since this outbreak became public: Gilead Sciences (GILD) and Moderna.

However, Moderna’s output is different from Gilead’s treatment.

For one, Gilead’s approach is to build upon or reuse an existing antiviral drug Remdesivir to develop a coronavirus cure.

In comparison, Moderna created a new vaccine from scratch and still managed to get ahead of the pack.

Both companies stand to win though since the two treatments won’t be directly competing against each other.

Gilead’s drug aims to cure people who are already suffering from the coronavirus disease while Moderna offers a vaccine to avoid infection.

Aside from working on the coronavirus disease solution, Moderna has recently announced another promising mRNA-based vaccine called mRNA-1647.

This vaccine seeks to offer treatment for cytomegalovirus (CMV), which is a virus related to those that cause infectious mono and chickenpox.

While this disease is most dangerous to newborn babies because it could cause birth defects when transmitted through the pregnant mother, this is a common virus that can affect almost everybody.

In the US alone, approximately 50% to 80% of adults have been infected by the time they reach 40. Once you get infected by CMV, the virus stays in your body for life.

According to Moderna, the results of the Phase 2 trial for the CMV vaccine should be out by the third quarter of 2020. If all goes well, the company will enter the next phase by early 2021.

Although Moderna’s true value will only emerge when the company actually brings a product to market, it’s 32.5% jump in the first two months of this year is still noteworthy.

The fact that it is on track to deliver potentially lifesaving drugs in the form of the coronavirus and CMV vaccines also makes it a first-rate hedge against this current anxious and fearful market.

 

https://www.madhedgefundtrader.com/wp-content/uploads/2020/03/moderna.png 456 750 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-03-10 15:00:292020-12-18 00:24:46A New Technology to Edit Genes Hits the Market
Mad Hedge Fund Trader

February 14, 2020

Diary, Newsletter

Global Market Comments
February 14, 2020
Fiat Lux

Featured Trade:

(FEBRUARY 12 BIWEEKLY STRATEGY WEBINAR Q&A)
(SQ), (TSLA), (FB), (GILD), (BA), (CRSP), (CSCO), (GLD)
(FEYE), (VIX), (VXX), (USO), (LYFT), (UBER)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2020-02-14 04:04:392020-02-13 17:36:49February 14, 2020
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