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Douglas Davenport

BLACK CAT, WHITE CAT, RED STOCKS

Mad Hedge AI

(NVDA), (MSFT), (GOOG), (AMZN), (META), (AAPL)

Back in 1976, during one of my assignments, a senior Chinese economist offered me a cup of tea and shared something Deng Xiaoping had once told them—words I’ve never forgotten: "It doesn't matter if the cat is black or white, as long as it catches mice." 

I found myself thinking about that conversation last week as I watched a small Chinese AI company, DeepSeek, snatch $1.2 trillion worth of mice right out from under Silicon Valley’s nose.

Earlier this month, a small Chinese AI lab called DeepSeek managed to vaporize $1.2 trillion in market value by doing something rather inconvenient: proving you don't need billions to build competitive AI models. 

Their founder, Liam Wenfeng, probably wasn't trying to start a panic. He just wanted to show that his team could match OpenAI's capabilities at 5% of the cost.

The market reaction was swift and brutal. Nvidia (NVDA), everyone's favorite AI golden child, watched its stock plummet 17% in early trading. 

The tremors hit the entire tech sector: Microsoft (MSFT) down 3.5%, Alphabet (GOOG) dropped 3%, and Amazon (AMZN) shed 2.4%. 

Even Meta (META) took a 1.4% hit. Apple (AAPL), being Apple, somehow managed to gain 1.2%. There's always one kid in class who has to be different.

Let's talk about what DeepSeek actually did. Their R1 model, built for a mere $5.57 million using Nvidia's H800 chips, is matching OpenAI's GPT-4 in math, coding, and reasoning benchmarks. 

They used pure reinforcement learning - basically letting the AI figure things out on its own rather than holding its hand through the process. And it worked.

The timing is almost comical. Just as OpenAI's Sam Altman was at the White House announcing the $500 billion Stargate Project, DeepSeek showed up with their bargain-basement solution that performs just as well. 

Even Nvidia had to acknowledge the achievement, calling it an "excellent AI advancement." When your competitors start complimenting you, you know you've struck a nerve.

But here's what Wall Street might be missing: this isn't just about cost reduction. 

DeepSeek released their model under an MIT license, meaning anyone can study, modify, and expand it. They're not just competing - they're changing the rules of the game.

What should we do? First, take a deep breath. 

Despite this disruption, the fact remains that the Magnificent 7 and U.S. tech companies are playing a longer game, focused on artificial general intelligence with an ecosystem that DeepSeek "cannot come close to." This could actually increase demand for computing resources - cheaper AI often leads to more AI usage, not less.

The $2 trillion of capital expenditure expected over the next three years isn't going away. If anything, this development might accelerate it. 

When technology gets cheaper, people tend to use more of it, not less. Just ask anyone who remembers when long-distance calls cost a fortune.

For investors, this looks more like a buying opportunity than a reason to panic. I've seen enough market disruptions to know that the initial reaction is usually overdone. 

The AI infrastructure build-out is just getting started, and cheaper development costs could actually expand the market rather than shrink it.

Keep your eyes on DeepSeek, though. The tech giants will need to adapt - either by making their own processes more efficient or by finding new ways to add value. Competition has a funny way of improving everyone's game.

And somewhere in Beijing, I imagine there's a tech executive reciting that old proverb about cats and mice, knowing they just caught the biggest mouse of all - Wall Street's attention. 

Some market lessons never get old, even if the cats keep changing their colors.

https://www.madhedgefundtrader.com/wp-content/uploads/2025/01/Screenshot-2025-01-31-163709.png 591 665 Douglas Davenport https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Douglas Davenport2025-01-31 16:38:012025-01-31 16:38:33BLACK CAT, WHITE CAT, RED STOCKS
april@madhedgefundtrader.com

January 31, 2025

Tech Letter

Mad Hedge Technology Letter
January 31, 2025
Fiat Lux

 

Featured Trade:

(AMAZON CUTS OFF THE OUTSIDE)
(AMZN), (UPS)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2025-01-31 14:04:292025-01-31 14:42:29January 31, 2025
april@madhedgefundtrader.com

Amazon Cuts Off The Outside

Tech Letter

UPS cutting back their logistics agreement by 50% with Amazon (AMZN) is not a bug, but a feature of what is to come in 2025 and beyond.

I believe we are at an inflection point where anything and everything that these big tech companies can source in-house, they will do.

That means Amazon going full-on 100% with their own transport, logistics, and everything else.

They already steal popular 3rd party product designs and manufacture them themselves under their own brand and then sell it on their own website.

This type of behavior will go into overdrive and beyond in 2025.

The writing is on the wall for many small businesses and the leanness in tech companies is also reflected in their aggressive job cuts that started at the end of 2023.

UPS and FedEx will need to find a different source of volume moving forward because e-commerce packages will be operated by tech couriers.

This big pullback in Amazon deliveries sent UPS’s stock off a cliff.

The news has translated into their stock diving from $136 per share to $114 today.

That is just the beginning for many of these tech and non-tech partnerships and I believe we will see more severing off the cord in 2025.

One big trend is also semiconductor chips with the likes of Apple producing their mobile chips themselves.

A deal to cut business with its largest customer will be hard to make up for UPS, and for Amazon, it is great long-term news for the stock.

UPS said it reached an agreement in principle with its largest customer to lower its volume by more than 50% by the second half of 2026. In UPS's latest annual report, the company singled out Amazon and its affiliates, saying they represented about 12% of its revenue, nearly all in its U.S. package business.

Insourcing allows you to have more control over the tasks you have to do. It often involves adding more people to the company’s workforce or investing in training for people already in the company. It also requires new technologies that would otherwise have to be outsourced.

It is the opposite of outsourcing, where services or job functions are contracted from a third party, this is, a company or freelance outside of the organization.

The benefits outweigh the cons.

Amazon will have more control over processes and communication.

There is sensitive information that Amazon is giving out to third parties and these are trade secrets. Ending the partnership will go a long way to keeping data private.

By keeping things in-house, security and information leakage risks are reduced.

The exchange of new knowledge and social capital are positive impacts that insourcing can have. With insourcing strategies where people are trained and more synergies will occur, Amazon will revolutionize the concept of work.

I can envision the day when most of Amazon’s business isn’t outsourced. I mean sure, they cannot insource NFL streaming, but Amazon can produce the video instead of paying an outside contractor to do it.

After 2020, product quality is a real issue and Amazon taking back the initiative while going real lean with operations will ensure they beat quarterly earnings for the foreseeable future.

After hitting a short-term low of $160 last August, the stock has risen to all-time highs of $240 per share today.

I expect traders to continue to buy the dip in Amazon stock.

 

 

 

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april@madhedgefundtrader.com

January 31, 2025

Jacque's Post

 

(SUMMARY OF JOHN’S JANUARY 29, 2025, WEBINAR)

January 31, 2025

 

Hello everyone

 

TITLE “Reality Calls”

 

TRADE ALERT PERFORMANCE

January 2025 MTD +3.02%

Average annualized return = +50.02% for 17 years

Trailing One Year Return = +82.88%

PORTFOLIO REVIEW

Risk On

(TSLA) 2/$300-$310 call spread (10%)

(NVDA) 2/$90-$95 call spread (10%)

(VST) 2/$100-$110 call spread (10%)

Risk Off

(TSLA) 2/$540-$550 spread (10%)

 

THE METHOD TO MY MADNESS

2025 rally gets cut in half.

Market has gone from non-risk to high-risk overnight, with the leading names, like (NVDA) taking the biggest hits.

All interest rate plays remain dead in the water, including gold, silver, homebuilders, bonds, and REITS.

Deregulation and end of antitrust plays will continue to be bought, including banks, brokers, money managers, but maybe not nuclear, and Tesla.

US dollar finally takes a break on falling rates.

Big technology stocks get crushed by Deep Seek, small ok.

Energy sells off on Deep Seek as well, no power is needed.

Buy financial as the only sure thing this year.

 

THE GLOBAL ECONOMY – COOLING

Fed stays put with interest rates.   Fed Minutes are turning hawkish.

Consumer Price Index cools at 0.2% or 3.2% YOY, the first drop in six months.

25% tariffs on Mexico and Canada will raise the US inflation rate by 1.0%

US Consumer Confidence dives amid renewed concerns about the labor market and inflation.

2025 Economic forecasts are all over the map, as confusion reigns supreme over the impact of coming tariffs.

Credit Card delinquencies soar.

U.S. Business Activity slowed to a nine-month low.

The Tariff wars have started.

 

STOCKS – PUNCH TO THE NOSE

Technology stocks destroyed on news of China’s Deep Seek.

Nvidia drops $600 billion in market capitalization, the largest in stock market history.

Morgan Stanley warns customers to cut stock exposure.

The Cruise business is rocketing, with Royal Caribbean (RCL), just running up its best five-week sales period in history.

JetBlue (JBLU) gets destroyed, knocking 25% off of the stock.

Lockheed Martin (LMT) dives 8% on a cautious outlook spurred by our new government.

EV and Hybrid Sales reach a record 20% of US vehicle sales in 2024.

 

BONDS – STABILIZING

Bonds have stalled near two-year lows, yields down to 4.53%

All fixed-income plays have gone dead.

“Higher Rates for longer” don’t fit in here anywhere.  But there may be a BUY setting up for (TLT) at 5.0%.

Bond yields have rocketed 130 basis points since September.

National Debt tops record $36 trillion and could rise another $10 trillion.

TIPS are making a comeback.

 

FOREIGN CURRENCIES – FINALLY A WEAK US DOLLAR WEEK

Dollar backs off two-year high on interest rate pull back.

Ten-year US Treasuries have risen from 3.55% to 4.80%, then 4.53%.

The mere fact that rates have stalled has allowed currencies to rally.

Higher for longer interest rates mean higher for longer US dollar.

Don’t sell short the US dollar until the next recession is on the horizon.

Avoid (FXA), (FXE), (FXB), (FXC), and (FXY).

 

ENERGY & COMMODITIES

Deep Seek shock trashes all nuclear energy plays on fears that the new orders will be cancelled, as the extra power will no longer be needed.

New AI programming uses 1% of the chips, and therefore 1% of the power.

Nothing could be further from the truth.  Buy all nuclear plays on this dip.

Ban lifted on new natural gas export facilities in 4 years, reversing a climate era climate initiative.

Many analysts expect an oversupplied oil market this year after demand growth slowed sharply in 2024 in the top consuming nations: the U.S. and China.

The EIA said it expects Brent Crude oil prices to fall 8% to average $74 a barrel in 2025, then fall further to $66 a barrel in 2026.

 

PRECIOUS METALS – STRUGGLING TO RECOVER

Gold has recovered half of the post-election losses on the central bank and Chinese flight to safety buying.

Interest rates higher for longer is a death knell for precious metals, with gold down 8.3% after November 5.

Gold has become the only way the average Chinese can save as they can no longer speculate in real estate or copper and don’t trust the Chinese Yuan, so there is support lower down.

Central banks in emerging market countries are continuing to buy gold, with 693 metric tonnes of buying, or $5.3 billion this year.

Avoid (GLD), (SLV), (AGQ), and (WPM)

 

REAL ESTATE – POOR OUTLOOK

Single Family Home starts plunged 6.9% in October.

Home Insurance costs are soaring for homeowners in the most affected regions, California and Florida.

U.S. Home Sales hit a 30-year low in 2024, the second year in a row of weak sales.

Housing starts were up 3.0% in December, with single-family homes up only 3%, while multifamily saw a 59% rise.

Shift away from home sales – crushed by 7.2% mortgage rates.

You can write off real estate in 2025.

 

TRADE SHEET

Stocks – buy the next big dip

Bonds – sell rallies

Commodities – stand aside

Currencies – stand aside

Precious Metals – stand aside

Energy – buy nuclear dips

Volatility – sell over $30

Real Estate – stand aside

 

NEXT STRATEGY WEBINAR

12:00 EST Wednesday, February 12, 2025, from Incline Village, NV.

 

Jacquie’s Post Portfolio Update

We are going to take some profits.

 

SELL

Equinix (EQIX)

Purchased on February 21, 2024, at $900.00

Price on January 30th, 2025, = $922.13.

Sell and take profits today at the best price.

 

Jacquie’s Post January Zoom Meeting

Thank you to all those who attended the meeting yesterday.  It was great to see you all there.  See you next month.

 

 

Cheers

Jacquie

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2025-01-31 12:00:432025-01-31 12:03:34January 31, 2025
april@madhedgefundtrader.com

January 30, 2025

Diary, Newsletter, Summary

Global Market Comments
January 31, 2025
Fiat Lux

 

Featured Trade:

(JANUARY 29 BIWEEKLY STRATEGY WEBINAR Q&A),
(META), (AMZN), (NVDA), (AMD)  (GS), (SPY), (TSLA), (SBUX), (CCJ), (ADBE), (LMT), (GD), (RTX), (NVDA)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2025-01-31 09:04:542025-01-31 09:52:52January 30, 2025
april@madhedgefundtrader.com

January 29 Biweekly Strategy Webinar Q&A

Diary, Newsletter

Below please find subscribers’ Q&A for the January 29 Mad Hedge Fund Trader Global Strategy Webinar, broadcast from Salt Lake City, UT.

Q: Are AI stocks going to crash?

A: Some already have, and others haven’t. It’s really about single-stock-picking the chip area and the pure AI plays, which have been enormously overextended. If you boil it down to a single sentence, if you offer AI for free, AI users like (META) and (AMZN) do really well, while AI producers, like (NVDA) and (AMD) get crushed. I’ve been warning for months that these things were getting too high. The end result is that in two weeks the price earnings multiple for Nvidia has gone from 40 to 25. You know, at 25, it really is quite attractive. It'll be even more attractive at 20 or even 15 if we get that low. I'll show you where we hit that on the charts. Don't forget their earnings are still growing at tremendous rates—we'll talk about that in a second.

Q: What stocks are good to invest in now?

A: Watch the banks. Watch the financials. They’ve hardly sold off. I was begging for Goldman Sachs (GS) to tank. It didn't—we only got a $10 drop. It's just not letting people in, which means higher highs for all the banks and financials are coming. That has become the no-brainer one-way trade of 2025. You know, I had an enormous number of bank LEAPS expire in my personal account on the January 17 option expiration. I'm waiting to get back in now. So that is the play.

Q: What's happening with Starbucks (SBUX)? Are they investable?

A: Starbucks was a disaster area until the summer when they brought in new management, which has a fantastic track record. The stock has since gone up 30%. You're kind of late to get in on this one. I don't really follow the stock anyway. Selling cups of coffee is not a high-margin business. I'd rather stick with the Tesla’s (TSLA) and Nvidia’s (NVDA) of the world where the value added is very high

Q: What will happen with Bitcoin in the new administration?

A: It's the same with everything. Higher highs first, lower lows later. If you're a Bitcoin investor now at 100,000, the big question is what happens when Donald Trump leaves office in four years? Does it go back to 5,000? We really don't know so, why touch Bitcoin when you can get 10 to 1 returns on all these other great companies which make stuff that you can actually touch and feel? Plus, you can leverage up with the LEAPS, and no one's going to steal your account, which happens frequently with Bitcoin holdings.

Q: Do you think tariffs are a good idea for the economy?

A: No, tariffs shrink global trade, they shrink globalization. It's a race to see if we can make other countries more poor than they can make us. It's an economy-shrinking strategy. It was a major contributor to causing the Great Depression in the 1930’s. That's why we abandoned tariffs 80 years ago with the end of World War II. I mean, the last cause of the 1930’s tariffs was World War II. That was a major contributing factor. So do I like tariffs? No. It turns out it's a great defensive strategy. If someone's making a fortune off you, they tend not to blow you up. So I think that's a big mistake and I will be an anti-tariff person to my grave. There are special situations like Chinese EVs, for example, where they're using a huge cost advantage to flood the emerging markets with cheap EVs. If that happened to the US, it would crash the US economy. In that one case, I'm in favor of tariffs. By the way, their EVs are using technology they basically stole from Tesla.

Q: What are your thoughts on defense stocks? With so many wars occurring all over the world.

A: Don't touch defense stocks with a 10-foot poll if the government is in favor of cost-cutting, the largest cost after Social Security is defense. We had a defense budget of about $824 billion in 2024. We have a 2.8 million man military and that cutting there and running down our weapons stocks would mean that you don't want to buy Lockheed Martin (LMT), General Dynamics (GD), Raytheon (RTX), all the big suppliers of weapons to the Ukraine war, for example, which looks like it's going to get cut off completely. They cut off all humanitarian aid to Ukraine last week. And of course, I was personally involved in delivering some of that humanitarian aid to Ukraine in the recent past. Yeah, defense looks bad if people really get serious about cost-cutting.

Q: Do you see the Fed dropping interest rates later this year?

A: That is possible. I tend to think we don't go into recession this year. It's a next year or year after type of thing. But markets can discount recession in six months to a year in advance like they did in 2007 and 2008. I don't think we get any more interest rate cuts. We'll just have to see what policies the new government implements, and how inflationary they are. And if they are inflationary, interest rates are going up, not down. That is why everybody's sitting on their hands right now and doesn't know what to do. Uncertainty at an eight-year high. You know, the government often talks one game but does the opposite. So, there’s nothing to do but wait and see.

Q: Well, what happened to the US housing market in 2025?

A: Nothing, you know volumes are shrinking. The last two years were the lowest volume sales in housing market history since the numbers were collected, and higher interest rates for longer. It's just more bad news. You know, something like 40% of all of the sales now are all cash. Prices are still going up again on paper, but there's almost no trade happening at these higher prices. And of course, the Millennials have been almost completely shut out of the market—the largest generation in history by the way—because they don't have enough money. They can't earn enough money; especially when AI is wiping out all the entry-level jobs, as it has been doing for two years in Silicon Valley.

Q: Here's a good question. How much time do we need to spend researching a company before we make an investment there?

A: Well, not that much, really. You can spend an hour or two reading the annual report, browsing through the most recent financial statement, and doing some news searches and you'll have a better read than most individual investors are going to have on a single stock. Then you start to see trends on what makes a good company, what makes a bad company, and over time, you get a feel for a company—when to get in, when to get out. That's one way. Or you can listen to the Mad Hedge Fund Trader, who's been doing this for 55 years and watching the same stocks. You wonder why you always have the same stocks up here and it's because I've been following these guys for forever or more. So you really get a handle on when they're doing well and when they're doing awful.

Q: Should we sell Nvidia (NVDA) stock for now?

A: No, I was telling people to cut positions the next time it ran to $150, which it did a few weeks ago. Now we're probably entering buy territory more than sell territory. Nvidia will come back. I just don't know where the bottom is for now, and it depends on your own investing style. If you're a five-year investor, you can forget about all this volatility, if you're a day trader, yeah, you probably should sell Nvidia now because you could buy it back $10 cheaper.

Q: Do you expect a new high after the Fed meeting?

A: No, I don't. I think we're stuck in a range for the S&P 500 for the next six months. After that, we may get a move. Depending on what effect government policies have on the economy.

Q: What about an alert for Adobe (ADBE)?

A: I didn't put out the alert to buy Adobe. The Adobe alert is part of the Mad Hedge Technology Letter service, and if you want to get purely tech trade alerts, go to the Mad Hedge website, go to the store, and you can see the technology letter is offered for sale up there. Here is the link: https://hi290.infusionsoft.app/app/orderForms/techletter

Q: ​​What is the right size of account for doing this kind of trading?

A: We literally have college students trading with $500 accounts. We have lots of individuals trading with $5,000 accounts—that way you can buy 10 $400 positions and still have some room. We only recommend you put 10% of your cash in any one trade. A lot of retired people will keep a large portion of their money in an index like the S&P 500 (SPY) and take 10% of their money and use it to do our trade alerts, which then adds an extra return to the index position. So, the answer is different for different people.

Q: Do I see a meaningful correction like 20% or 30% in the next six months?

A: No, I really don't, but that could be 2026 business. When we get a big correction, we get a recession. Again, it's dependent on government policies and we have no idea what those are right now. People can only guess. I'm not in the guessing business. I'm in the sure thing business.

Q: Can you explain how to complete the trade alerts you send out?

A: What all the professionals do is they put out a spread of orders. If I put out an order to buy something at $9.00, you put in a bid at $9.00, $9.10, $9.20, $9.30, and $9.40. By the close, some or all of those will get done. Often they all get done by the end of the day when the high-frequency traders have to dump their positions because they're not allowed to carry overnight positions. You make them good-until-canceled orders. So if you get a low opening the next morning, you'll get entirely filled at the $9.00 level, and this is what my clients in Australia do. They only do overnight good-until-cancelled orders since the market's open from 11:30 PM until 6:00 AM  in the morning, Australia time. They tend to make more money than any of my other clients because they only enter overnight GTC orders. So, people trying to outsmart the market on an intraday basis generally don't do very well.

Q: Should I sell the Cameco Corporation (CCJ) stock I bought on the nuclear trade?

A: No, I think (CCJ) recovers. I was looking at it yesterday. Elimination of the electricity trade is complete nonsense. I think the nuclear thing is real. It'll come back. And in fact, I bought Vistra Energy (VST) yesterday, so use this extreme sell-off to get into the nuclear trade if you missed it the first time around.

To watch a replay of this webinar with all the charts, bells, whistles, and classic rock music, just log in to www.madhedgefundtrader.com, go to MY ACCOUNT, click on GLOBAL TRADING DISPATCH, TECHNOLOGY LETTER, or JACQUIE'S POST, then WEBINARS, and all the webinars from the last 12 years are there in all their glory.

 

Good Luck and Good Trading,

John Thomas
CEO & Publisher
The Diary of a Mad Hedge Fund Trader

 

 

 

 

 

 

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Mad Hedge Fund Trader

January 31, 2025 - Quote of the Day

Tech Letter

“Jeff Bezos is opening a retail store and owns a newspaper. Turns out everything we thought about the Internet is wrong.” - Co-Founder and CEO of Box Aaron Levie

https://www.madhedgefundtrader.com/wp-content/uploads/2018/03/Aaron-Levie-e1521658165668.jpg 294 400 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2025-01-31 09:00:282025-01-31 09:48:46January 31, 2025 - Quote of the Day
april@madhedgefundtrader.com

January 30, 2025

Biotech Letter

Mad Hedge Biotech and Healthcare Letter
January 30, 2025
Fiat Lux

 

Featured Trade:

(A CRITICAL PAIN POINT)

(VRTX), (AMZN)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 april@madhedgefundtrader.com https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png april@madhedgefundtrader.com2025-01-30 12:02:362025-01-30 12:18:39January 30, 2025
april@madhedgefundtrader.com

A Critical Pain Point

Biotech Letter

Last week, while having dinner with an old friend who's an emergency room physician in San Francisco, I heard a story that stopped me cold. She had just lost another patient to an opioid overdose - the fourth one that month.

"We desperately need alternatives," she said, pushing away her plate. "Something that works without killing people."

She's not wrong. More than 80,000 Americans died from opioid overdoses in 2022 alone - that's about 75% of all drug overdose deaths in the country.

To put that in perspective, that's more than double the number of people who die in car accidents each year. In New York alone, opioid-related deaths have quadrupled between 2010 and 2020.

You can see where this is going. There's a massive market opportunity here for any company that can crack the code of non-addictive pain management.

We're talking about a potential market worth tens of billions of dollars. The holy grail? A drug that works as well as opioids without the devastating addiction potential.

Enter Vertex Pharmaceuticals (VRTX) and their sodium channel inhibitor VX-548, now known as suzetrigine. The company has been quietly plugging away at this problem, and I've been watching them like a hawk.

For those who've been following my previous coverage, you'll remember I wrote about their interesting (though modest) results in post-surgical patients a few months ago.

And here's where it gets fascinating. Vertex has been running multiple trials because - as any doctor will tell you - pain isn't just pain.

It comes in more flavors than Ben & Jerry's ice cream: acute, chronic, neuropathic, cancer-related, post-surgical, and don't even get me started on phantom limb pain.

Just before the holiday break, they dropped their latest results for suzetrigine in sciatica patients.

Now, I have to tell you something that might sting a bit. The drug worked - but so did the placebo. Both groups saw their pain decrease by statistically similar amounts.

Vertex argues the placebo response was unusually high and that a larger Phase III trial should smooth things out.

Maybe they're right - but I've seen enough clinical trials to know that placebo effects in pain studies can be trickier than a Wall Street hedge fund manager.

The FDA is expected to make a decision by the end of this month on suzetrigine for moderate-to-severe acute pain.

Despite the recent speed bump in the sciatica trial, I'm still keeping my eye on the bigger picture here. Vertex isn't a one-trick pony.

Their cystic fibrosis (CF) portfolio is absolutely crushing it. They just got FDA approval for Alyftrek ahead of schedule.

They've expanded Trikafta's approval down to patients as young as two years old, which is huge for their market potential. Plus, they’ve been aggressively pushing into international markets over the past months.

Now, let's talk numbers. Suzetrigine revenue is projected to hit $5 billion by 2035. That's not chump change, even if we hit some bumps along the way.

Trading at a P/S multiple of almost 10, Vertex isn't cheap - but then again, neither was Amazon (AMZN) in 1997.

Still, this biotech’s pipeline goes beyond pain management. We're looking at treatments for diabetic peripheral neuropathy, IgA nephropathy, type 1 diabetes, and even gene editing therapy.

So, here's the bottom line: Yes, the market got spooked by the Phase II data. Yes, there are risks. But remember - the FDA is under enormous pressure to approve non-opioid painkillers.

With 80,000 Americans dying yearly from opioid overdoses, they need solutions more than my trader friends need their morning coffee.

I'll keep watching this one closely. The pain management market is like a sleeping giant, and despite the recent hiccup, Vertex might just have the alarm clock.

or long-term investors, this could be one of those "I wish I bought it back then" moments.

Watch this space. The opioid crisis isn't going anywhere, but neither is Vertex's determination to solve it.

Sometimes the biggest opportunities come disguised as disappointments.

 

 

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Trade Alert - (MSFT) January 30, 2025 - BUY

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When John identifies a strategic exit point, he will send you an alert with specific trade information as to what security to sell, when to sell it, and at what price. Most often, it will be to TAKE PROFITS, but, on rare occasions, it will be to exercise a STOP LOSS at a predetermined price to adhere to strict risk management discipline. Read more

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