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april@madhedgefundtrader.com

Slicing Through Doubt

Biotech Letter

In the intricate world of medical breakthroughs, September 14, 1990, stands out like a sore thumb—or perhaps, a healing one.

On this day, the baseball world was left agog as Ken Griffey Jr. and Sr. knocked out back-to-back home runs, a feat as rare as hen’s teeth.

Meanwhile, in a quieter corner of the planet, a medical marvel was unfolding. Ashanti DeSilva, a 4-year-old with a genetic disorder ravaging her immune system, was about to become the poster child for gene therapy, receiving a groundbreaking treatment that involved a cocktail of modified white blood cells. The aim? To supercharge her immune system and give her a fighting chance at a normal life.

But let’s not sugarcoat it—the road from there to here was anything but a walk in the park. Gene therapy, the promising prodigy of the biotechnology and healthcare sector, had its fair share of teenage rebellion, grappling with safety concerns and delivery vehicle dilemmas. It wasn’t until the early 2010s when gene correction technologies got their act together and safer delivery systems stepped onto the scene, that gene therapy started living up to its potential.

Enter Sickle Cell Disease (SCD), the blood disorder that’s been playing hard to get, affecting around 70,000 Americans and causing everything from anemia to organ damage.

The cure seemed as elusive as a winning lottery ticket until exa-cel, the brainchild of CRISPR Therapeutics (CRSP) and Vertex Pharmaceuticals (VRTX), entered the scene.

This therapy, wielding the mighty CRISPR/Cas9 like a genetic scalpel, takes a patient's stem cells on a rollercoaster ride—harvesting, modifying, and infusing them back into the patient, with the end goal of producing healthy red blood cells.

Looking ahead, CRISPR Therapeutics and Vertex are gearing up for a potential launch of exa-cel in 2024, assuming all the stars align. This innovative gene therapy is poised to be a significant growth catalyst for both companies in the coming decade. Initially, the focus will be approximately 32,000 patients suffering from SCD and TDT.

However, investors need to brace themselves for the price tag, as gene editing therapies don't come cheap. The cost for exa-cel is anticipated to be well north of $1 million, reflecting the complexity and value of this cutting-edge treatment.

At this point, it's crucial to acknowledge that exa-cel is not the only player in this high-stakes game.

A variety of other gene therapies are also vying for the spotlight, with contenders like Bluebird Bio's (BLUE) lovo-cel, Beam Therapeutics' (BEAM) innovative base-edited candidates, and Editas Medicine's (EDIT) competitive CRISPR/Cas9 therapy all in the running.

Now, let’s talk turkey. The financial forecast for exa-cel is looking bright, with CRISPR Therapeutics poised to tap into a $48 billion market opportunity.

Although the treatment has yet to gain FDA approval, the company already has its ducks in a row. It set up 50 treatment centers in the US and 25 in Europe, as well as schmoozed with commercial payers to ensure exa-cel is as accessible as a cold beer on a hot day.

Still, let’s not put on our rose-colored glasses just yet. The biotech sector is as fickle as a cat on a hot tin roof, with CRISPR Therapeutics’ market cap doing the cha-cha in response to industry volatility. With a slew of gene therapies for SCD waiting in the wings, it’s a stark reminder that in biotech, it’s not enough to keep up—you’ve got to lead the pack.

Meanwhile, CRISPR Therapeutics is flexing its muscles with six other clinical trial programs targeting a spectrum of conditions from various cancers to type 1 diabetes, where it is ambitiously seeking a functional cure. With a robust $1.8 billion in cash, equivalents, and marketable securities as of the second quarter and a market capitalization of $3.2 billion, the company is in a strong financial position.

For the astute investors, the real gold is in playing the long game. Rather than getting caught up in the short-term ebbs and flows of the biotech market, the savvy should be pondering how to leverage the current market conditions to their advantage.

After all, CRISPR Therapeutics, with its pioneering gene-editing technology, has the potential to follow in the footsteps of biotech titans like Amgen (AMGN) and Regeneron Pharmaceuticals (REGN), both of which have turned early investments into veritable treasure troves.

Moreover, its financial stability, bolstered by its partnership with Vertex, ensures that funding woes common among smaller biotechs are less of a concern. While it may not be the largest or most prominent player in the biotech arena, the next decade could very well see CRISPR Therapeutics delivering returns that outpace the market. I suggest you buy the dip.

 

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april@madhedgefundtrader.com

November 2, 2023

Diary, Newsletter, Summary

Global Market Comments
November 2, 2023
Fiat Lux

Featured Trade:

(THE SECOND AMERICAN INDUSTRIAL REVOLUTION),
(INDU), (SPY), (QQQ), (GLD), (DBA),
(TSLA), (GOOGL), (XLK), (IBB), (XLE)
(TESTIMONIAL)

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Mad Hedge Fund Trader

The Second American Industrial Revolution

Diary, Newsletter

Circulating among the country’s top global strategists this year, visiting their corner offices, camping out in their vacation villas, or cruising on their yachts, I am increasingly hearing about a new investment theme that will lead markets for the next 20 years:

The Second American Industrial Revolution.

It goes something like this.

You remember the first Industrial Revolution, don’t you? I remember it like it was yesterday.

It started in 1775 when a Scottish instrument maker named James Watt invented the modern steam engine. Originally employed for pumping water out of a deep Shropshire coalmine, within 32 years it was powering Robert Fulton’s first commercially successful steamship, the Clermont, up the Hudson River.

The first Industrial Revolution enabled a massive increase in standards of living, kept inflation near zero for a century, and allowed the planet’s population to soar from 1 billion to 7 billion. We are still reaping its immeasurable benefits.

The Second Industrial Revolution is centered on my own neighborhood of San Francisco. It seems like almost every garage in the city is now devoted to a start-up.

The cars have been flushed out onto the streets, making urban parking here a total nightmare. These are turbocharging the rate of technological advancement.

Successes go public rapidly and rake in billions of dollars for the founders overnight. Thirty-year-old billionaires wearing hoodies are becoming commonplace.

However, unlike with past winners, these newly minted titans of industry don’t lock their wealth up in mega mansions, private jets, or the Treasury bond market. They buy a Tesla Plaid for $150,000 with a great sound system and full street-to-street auto-pilot (TSLA), and then reinvest the rest of their windfall in a dozen other startups, seeking to repeat a winning formula.

Many do it.

Thus, the amount of capital available for new ideas is growing by leaps and bounds. As a result, the economy will benefit from the creation of more new technology in the next ten years than it has seen in the past 200.

Computing power is doubling every year. That means your iPhone will have a billion times more computing power in a decade. 3D printing is jumping from the hobby world into large-scale manufacturing. In fact, Elon Musk’s Space X is already making rocket engine parts on such machines.

Drones came out of nowhere and are now popping up everywhere.

It is not just new things that are being invented. Fantastic new ways to analyze and store data, known as “big data” are being created.

Unheard new means of social organization are appearing at breakneck, leading to a sharing economy. Much of the new economy is not about invention, but organization.

The Uber ride-sharing service created $50 billion in market capitalization in only five years and is poised to replace UPS, FedEx, and the US Postal Service with “same hour” intracity deliveries. Now they are offering “Uber Eats” in my neighborhood, which will deliver you anything you want to eat, hot, in ten minutes!

Airbnb is arranging accommodation for 1 million guests a month. They even had 189 German guests staying with Brazilians during the World Cup there. I bet those were interesting living rooms on the final day! (Germany won).

And you are going to spend a lot of Saturday nights at home, alone if you haven’t heard of Match.com, eHarmony.com, or Badoo.com.

“WOW” is becoming the most spoken word in the English language. I hear myself saying I every day.

Biotechnology (IBB), an also-ran for the past half-century, is sprinting to make up for lost time. The field has grown from a dozen scientists in my day 40 years ago, to several hundred thousand today.

The payoff will be the cure for every major disease, like cancer, Parkinson’s, heart disease, AIDS, and diabetes, within ten years. Some of the harder cases, such as arthritis, may take a little longer. Soon, we will be able to manipulate our own DNA, turning genes on and off at will. The weight loss drugs Wegovy and Ozempic promise to eliminate 75% of all self-inflicted illnesses.

The upshot will be the creation of a massive global market for these cures, generating immense profits. American firms will dominate this area, as well.

Energy is the third leg of the innovation powerhouse. Into this basket, you can throw in solar, wind, batteries, biodiesel, and even “new” nuclear (see NuScale (SMR)).  The new Tesla Powerwall will be a game changer. Visionary, Elon Musk, is ramping up to make tens of millions of these things.

Use of existing carbon-based fuel sources, such as oil and natural gas, will become vastly more efficient. Fracking is unleashing unlimited new domestic supplies.

Welcome to “Saudi America.”

The government has ordered Detroit to boost vehicle mileage to an average of 55 miles per gallon by 2030. The big firms have all told me they plan to beat that deadline, not litigate it, a complete reversal of philosophy.

Coal will be burned in impoverished emerging markets only, before it disappears completely. Energy costs will drop to a fraction of today’s levels, further boosting corporate profits.

Coal will die, not because of some environmental panacea, but because it is too expensive to rip out of the ground and transport around the world, once you fully account for all its costs.

Years ago, I used to get two pitches for venture capital investments a quarter, if any. Now, I am getting two a day. I can understand only half of them (those that deal with energy and biotech, and some tech).

My friends at Google Venture Capital are getting inundated with 20 a day each! How they keep all of these stories straight is beyond me. I guess that’s why they work for Google (GOOGL).

The rate of change for technology, our economy, and for the financial markets will accelerate to more than exponential. It took 32 years to make the leap from steam engine-powered pumps to ships and was a result of a chance transatlantic trip by Robert Fulton to England, where he stumbled across a huffing and puffing steam engine.

Such a generational change is likely to occur in 32 minutes in today’s hyper-connected world, and much shorter if you work on antivirus software (or write the viruses themselves!). And don’t get me started on AI!

The demographic outlook is about to dramatically improve, flipping from a headwind to a tailwind in 2022. That’s when the population starts producing more big spending Gen Xers and fewer over-saving and underproducing baby boomers. This alone should be at least 1% a year to GDP growth.

China is disappearing as a drag on the US economy. During the nineties and the naughts, they probably sucked 25 million jobs out of the US.

With an “onshoring” trend now in full swing, the jobs ledger has swung in America’s favor. This is one reason that unemployment is steadily falling. Joblessness is becoming China’s problem, not ours.

The consequences for the financial markets will be nothing less than mind-boggling. The short answer is higher for everything. Skyrocketing earnings take equity markets to the moon. Multiples blast off through the top end of historic ranges. The US returns to a steady 5% a year GDP growth, which it clocked in the recent quarter.

What am I bid for the Dow Average (INDU), (SPY), (QQQ) in ten years? Did I hear 240,000, a seven-fold pop from today’s level? Or more?

Don’t think I have been smoking the local agricultural products from California in arriving at these numbers. That is only half the gain that I saw from 1982 to 2000, when the stock average also appreciated 17-fold, from 600 to 10,000.

They’re playing the same movie all over again. Except this time, it’s on triple fast forward.

There will also be commodities (DBA) and real estate booms. Even gold (GLD) gets bid up by emerging central banks bent in increasing their holdings to Western levels as well as falling interest rates.

I tell my kids to save their money, not to fritter it away day trading now because anything they buy in 2020 will increase in value tenfold by 2033. They’ll all look like geniuses like I did during the eighties.

What are my strategist friends doing about this forecast? They are throwing money into US stocks with both bands, especially in technology (XLK), biotech (IBB), and bonds (JNK).

This could go on for decades.

Just thought you’d like to know.

 

It’s Amazing What You Pick Up on These Things!

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Mad Hedge Fund Trader

Testimonial

Diary, Newsletter, Testimonials

Hello John,

I find your multi dimensional approach to markets are devoid of the usual Blah Blah Blah of most market analysts. It is very worthwhile, and I look forward to you using a lot of common sense and awareness.

That being said, regarding myself : I started trading gold in the late sixties and bought my first seat IMM at the CME in 1975 to trade currencies. I Mostly trade in sterling and yen. I had private tutoring on technical analysis on my day off from my regular job (which I love and still do).

Thanks for all you do.

Robert
Northfield, Illinois

2023 in Bucha Ukraine

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Mad Hedge Fund Trader

November 2, 2023 - Quote of the Day

Diary, Quote of the Day

'Nowadays, people know the price of everything and the value of nothing,' said Irish playwright, poet, and novelist, Oscar Wilde.

 

https://www.madhedgefundtrader.com/wp-content/uploads/2011/09/Oscar-Wilde.png 560 384 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2023-11-02 09:00:322023-11-02 12:10:32November 2, 2023 - Quote of the Day
Douglas Davenport

POWER PLAY

Mad Hedge AI

(MSFT), (GOOGL), (AMZN), (INTC), (AMD), (GE), (NEE), (BEP), (FSLR), (GCTAF)

In today’s technological renaissance, artificial intelligence (AI) is the crown jewel, poised to redefine a myriad of sectors. At the vanguard of this revolution is Microsoft (MSFT), a beacon of innovation, masterfully weaving together the threads of AI and nuclear fusion. These days, the tech giant is tackling head-on one of the most formidable challenges in AI: its voracious appetite for energy.

The proliferation of AI in our daily lives, exemplified by tools like OpenAI's ChatGPT, is leading to an unprecedented surge in energy demand. A study from the University of Washington lays bare the facts: hundreds of millions of queries on ChatGPT can guzzle up to 1 gigawatt-hour a day, equivalent to the energy consumption of 33,000 US households. This burgeoning demand for energy in the AI sector is sounding alarm bells about its long-term sustainability.

Microsoft, with its strategic foresight, is not turning a blind eye to this issue. The company’s partnerships and investments are a testament to its commitment to finding sustainable solutions. 

Its collaboration with OpenAI and the power purchase agreement with Helion Energy, which aims to harness nuclear fusion for energy by 2028, are pivotal moves. These are not mere ventures into sustainable energy; they are strategic investments ensuring the longevity and responsibility of AI’s power consumption.

Now, let’s shift our focus to the stock market and the investment opportunities that are unfolding. The tech-heavy Nasdaq (^IXIC) has witnessed a staggering 26% increase year to date, fueled largely by the buzz surrounding AI-related stocks. This underscores the profound impact AI is having on stock market investing. However, as expected, this impressive growth is not without its challenges.

The heart of advanced computing processes, data center electricity usage, has seen substantial growth. From 2010-2018, it increased by about 6%, and in 2022, global data center electricity consumption accounted for approximately 1.3% of global electricity demand. 

In real-life terms, this is comparable to the energy consumption of a small city's worth of homes running 24/7.

The shift in data centers from simpler processors (CPUs) to more advanced and energy-intensive graphics processing units (GPUs) is a significant factor in this increased energy demand. GPUs, now the backbone of AI infrastructure, consume 10 to 15 times more power per processing cycle than CPUs. 

This creates opportunities for companies like Intel (INTC), investing heavily in AI-compatible processors, and AMD (AMD), known for its high-performance computing and graphics technologies.

This transition, akin to moving from a versatile office worker (CPU) to a specialized assembly line (GPU), is crucial for the development and maintenance of sophisticated AI models but raises serious questions about the sustainability of such rapid growth.

So, what does this all mean for investors? Microsoft’s foray into AI and nuclear energy is a clear signal to investors about the transformative potential of a company that is not just riding the wave of AI but actively shaping its trajectory. Its focus on nuclear fusion shines a spotlight on companies in the energy sector, particularly those involved in nuclear technology and renewable energy.

For example, General Electric (GE) and NextEra Energy (NEE), both with significant investments in nuclear and renewable energy, could see a boost as the industry gains momentum. 

 

With Microsoft's investment in nuclear fusion, companies involved in nuclear energy and related technologies could become more attractive. Brookfield Renewable Partners (BEP) and Orano SA, a company specializing in nuclear fuel cycle products and services, are examples of companies in this sector.

Other tech giants with substantial investments in AI are likely to follow in Microsoft’s footsteps, seeking sustainable energy solutions for their AI operations. Major cloud providers, including Google Cloud (GOOGL), Microsoft Azure, and Amazon Web Services (AMZN), are already playing their part. They are investing heavily in renewable energy to offset their annual electricity consumption and have made net-zero pledges, committing to balance their carbon emissions with carbon removal.

So, companies that provide sustainable technology solutions and services also stand to gain as Microsoft and other tech giants seek to reduce their environmental footprint. First Solar (FSLR), a leading global provider of comprehensive photovoltaic solar systems, and Siemens Gamesa (GCTAF), a major player in the wind energy sector, are examples of companies in this space.

In essence, Microsoft's strategic integration of AI and nuclear energy is creating a domino effect, positively impacting a wide array of sectors and companies. This translates to a diversified portfolio of opportunities, ranging from tech giants and energy companies to startups and businesses focusing on sustainable solutions. 

The future is unfolding fast, and the investment landscape is ripe with possibilities for those ready to seize them. Don’t get left behind.

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Douglas Davenport https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Douglas Davenport2023-11-01 16:28:352023-11-01 16:28:35POWER PLAY
april@madhedgefundtrader.com

November 1, 2023

Jacque's Post

 

(THIS AI STOCK IS GAINING ATTENTION)

November 1, 2023

 

Hello everyone,

Welcome to November.

Wall Street is upbeat about an AI stock called Arista.

On Monday, the company earnings exceeded Wall Street expectations on both the top and bottom lines. 

Earnings:  $1.83/share

Revenue:  $1.51

Analysts forecast: 

Earnings:  $1.58/share

Revenue:  $1.48 billion

Arista also issued high-than-expected forward guidance, calling for fourth-quarter revenue in the range of $1.5 billion to $1.55 billion.

Arista’s focus is low-latency networks between clients and the cloud for large-scale data centres, exposing the company to growing investor interest in AI.

The stock is up 63% in 2023.

Analysts believe the company could be the top player in the Ethernet application of AI.  Morgan Stanley and Wells Fargo, among others applauded the company report and highlighted the company’s potential AI catalyst for growth heading into 2024.

Morgan Stanley’s Meta Marshall believes growth will accelerate from the adoption of 800G Ethernet transceivers for data centres.  Marshall upgraded Arista to overweight and gave the stock a price target of $220 which is more than 25% upside from Monday’s $175.72 close.

 

 

 

 

 

 

Market Update

U.S. 10-year Yields

We have been consolidating since reaching 5.0210% on October 23rd.  But we may have another leg up before exhaustion.

Possible targets:  5.25/5.33%

Support lies in the low/mid 4.80%’s.

Happy Wednesday to you all.

Cheers

Jacquie

 

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Mad Hedge Fund Trader

November 1, 2023

Tech Letter

Mad Hedge Technology Letter
November 1, 2023
Fiat Lux

Featured Trade:

(BYD IS HERE TO STAY)
(BYDDY), (TSLA), (EV)

https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png 0 0 Mad Hedge Fund Trader https://madhedgefundtrader.com/wp-content/uploads/2019/05/cropped-mad-hedge-logo-transparent-192x192_f9578834168ba24df3eb53916a12c882.png Mad Hedge Fund Trader2023-11-01 15:04:502023-11-01 16:37:51November 1, 2023
Mad Hedge Fund Trader

BYD is Here to Stay

Tech Letter

Tesla’s (TSLA) recent underperformance is a canary in the coal mine of what could become of the global EV industry.

EV makers better watch out because the race to zero is coming for all of them.

It could be yet another tech industry captured by the Chinese. The Chinese are quickly rising up the food chain of technological capabilities and these new developments are sure to rattle the White House.

I remember years ago when the Chinese tried their best at smartphones, they were terrible, but fast forward to today, and now they compare close to the iPhone with much better pricing.

Now, the Chinese are coming after electric cars and I also remember touring EVs in China in 2007 and they again were pretty terrible.

However, fast forward to today, and yet again they have achieved major inroads in terms of quality and reach. BYD Company Limited (BYDDY) even produces something comparable to Tesla which is no small feat.

Tesla’s disappointing third-quarter deliveries highlight the panic state side where the first mover advantage has served CEO Elon Musk well but eroded lately.

Tesla sold 435,000 electric cars last quarter, while BYD sold 431,000 battery-powered electric cars over the same period.

Expect BYD to surge past Tesla in delivered electric cars soon because they have access to a vastly bigger market while the Chinese communist party is doing everything to ruin American corporate business in the Middle Kingdom.

BYD is already far ahead when it comes to total sales. Including hybrids, BYD sold over 800,000 cars last quarter, almost twice as much as Tesla.

The Chinese company sold 1.8 million cars last year, over 911,000 of which were BEVs. Tesla, which only sells BEVs, sold 1.3 million cars.

Musk had previously warned that planned upgrades to manufacturing plants around the world may lead to lower deliveries for the rest of the year.

Tesla is also facing sluggish demand, forcing it to launch aggressive price wars in both China and the U.S.

BYD has surged ahead of its competitors in China by selling more affordable electric vehicles, unlike the premium models sold by Tesla and other EV companies like Nio and XPeng. BYD recently unseated Volkswagen as China’s top-selling car brand.

The company is expanding outside of China and is now the top-selling EV brand in markets like Thailand, Israel, and Singapore. It’s even expanding into more developed markets like Japan and Europe.

Watch out for China’s BYD to hijack Western markets moving forward including Europe, Canada, the United States, and the UK.

It’s finally time to stop ignoring that China does a good job producing EVs and other hard-to-manufacture technology.

My guess is that China will also surpass the United States in semiconductor chip technology, although that will take longer to achieve.

The Pentagon has sounded the alarm bells after noticing huge improvements in chip know-how by the Chinese.

Competition is finally here for Musk after so many years of taking a free ride in the US and it’s about time. Now the rubber finally meets the road.

Readers with a high threshold of risk tolerance should look at BYD’s ADR (BYD) if shares experience a big dip then allocating a small portion of a portfolio to this equity makes sense.

Don’t forget there is now a high probability of Tesla losing its Shanghai factory in China once China seizes American businesses on the mainland. It doesn’t matter how much Musk kowtows to the communist party because this issue is far bigger than him or the EV business.

That threat has gone from almost 0 just recently to becoming somewhat plausible although still quite low. The tech world is accelerating at warp speed in 2023.

 

 

 

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Mad Hedge Fund Trader

November 1, 2023

Diary, Newsletter, Summary

Global Market Comments
November 31, 2023
Fiat Lux

Featured Trade:

(WHERE THE ECONOMIST BIG MAC INDEX FINDS CURRENCY VALUE),
(FXF), (FXE), (FXA), (FXE), (CYB)
(THE FALLING MARKET FOR KIDS)

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